LunaseeStudios / Shutterstock.com Drain Opener Hazardous Waste LunaseeStudios / Shutterstock.com Dispose of as Hazardous Waste Drain openers contain toxic chemicals and must be disposed of as hazardous waste. Don't Use in Toilets Unless the product is specifically designed for toilets, don’t use drain opener in one — it won’t work and may even damage a porcelain toilet. Ways to Reduce Try a Homemade Solution Before you use a heavy-duty drain cleaner, try a homemade solution made from less hazardous substances. Learn how to use baking soda and vinegar to clean and even unclog a drain.